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ABT-737 is a BH3 mimetic that acts as an inhibitor of Bcl-2, Bxl-xl, and Bcl-ω. ABT-737 exhibits anticancer chemotherapeutic and antithrombotic activities. ABT-737 is currently in clinical trials as one component of a combination therapy in the treatment of various cancers such as acute myelogenous leukemia (AML).

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2006-11-01 · Because ABT-737 targets only certain prosurvival proteins (Bcl-2, Bcl-x L, Bcl-w), its efficacy as a single agent is restricted to tumors where prosurvival Mcl-1 is low. We show that resistant cells can be sensitized to ABT-737 by approaches that downregulate, destabilize, or inactivate Mcl-1. ABT-737 induces apoptosis through the mitochondrial pathway in ALL cells. Cells were treated for 24 hours with 100 nM ABT-737 or DMSO, or pretreated for 1 hour with 200 μM ZVAD.fmk prior to addition of ABT-737. (A) PARP cleavage correlates with cell death, as analyzed by annexin-V staining and reported as percent alive. ABT-737 induces the transcriptional activation of IL-6 and IL-8 We have identified a group of cancer cell lines (8) that are resistant to the proapoptotic activity of ABT-737.

Abt 737

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343 f., RANINEN, Vahvistuskirje sopimuksen  finansieringskostnaderna har SAS avtalat om att refinansiera två Boeing 737 och fyra Airbus A319 med en kreditfacilitet om 75 MUSD med  102 67 STOCKHOLM. Tel 08-737 70 00 Fax 08-737 71 45 typ av upphandlingar; AB 04, ABT 94 och ABK 96. För att underlätta för våra. MEK-inhibering ökar ABT-737-inducerad leukemicell-apoptos via förebyggande av ERK-aktiverad MCL-1-induktion och modulering av MCL-1 / BIM-komplex. Granzyme B utlöser ett långvarigt tryck för att dö i Bcl-2 överuttryckta celler, vilket definierar ett fönstermöjlighet för effektiv behandling med ABT-737. 2021-03-28. 2 737.

体外研究, ABT-737降低BCL-2/BAX异质二聚体，而诱导HL60细胞凋亡，但是对 细胞周期分布没有抑制效果。ABT-737也诱导细胞色素C从线粒体中释放，促进 BAX 

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BH3 Mimetic ABT-737 is an orally bioavailable, selective small molecule B-cell lymphoma 2 (Bcl-2) Homology 3 (BH3) mimetic, with potential pro-apoptotic and antineoplastic activities. ABT-737 binds to the hydrophobic groove of multiple members of the anti-apoptotic Bcl …

Abt 737

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Abt 737

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Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. 2007-01-15 ABT-737 inhibits many SCLC cell lines including NCI-H889, NCI-H1963, NCI-H1417, NCI-H146 and etc. Bcl-2 and Noxa may contribute mechanistically to the cellular response to ABT-737 in NCI-H146 cells. A recent study shows that ABT-737 significantly induces apoptosis in HTLV-1 infected T-cell lines as well as in fresh AT MedChem Express HY-50907 ABT-737 Cat. No.: A8193 CAS No.: 852808-04-9 Formula: C42H45ClN6O5S2 M.Wt: 813.43 Synonyms: ABT 737, ABT737 Target: Apoptosis Pathway: Bcl-2 Family Storage: Store at -20°C In Vitro ≥40.67mg/mL in DMSO,insoluble in EtOH,insoluble in H2O Preparing Stock Solutions Mass Solvent 1mg 5mg 10mg Concentration 1 mM 1.2294 mL 6.1468 mL 12.2936 mL Bcl-2 Inhibitor VI, ABT-737 - CAS 852808-04-9 - Calbiochem.
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ABT-737 is demonstrated to fully reverse the blockage of Myr-Bid-induced cytochrome c release by Bcl-2 in mitochondria preparations from Bcl-2 overexpressing FL5.12 cells and effectively inhibit the growth of numerous cancer cells both in cultures in vitro (IC 50 ≤100 nM against H146 and H1963) and in vivo (complete regression of H146 and H1963 in xenograft mice at 100 mg/kg/day, i.p.).

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Konditorns med Nina Söderquist - Ge mej, ge mej, ge mej The BH3 mimetic drug ABT-737 induces apoptosis and acts Theatre & Stage Uncertified Original 

34 773. 2 571. 61. FAST.KOSTN. standardavtalet ABT 06 som grund. Kommunen och  Klockorb2b.se Den största Svenska websidan för försäljning av klockor, smycken, solglasögon och andra acessoarer från de mesta välkända varumärkerna.

ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).

The aim of this study is to investigate whether DMC would sensi-tize GC cells to ABT-737 by regulating the Mcl-1 level. We here showed that DMC exhibited stronger synergistic effect than celecoxib in combination with ABT-737 in GC cells. The apoptosis induced by ABT-737; Abt-737 Substances of Biological Interest active profile. Top Gene Interactions. Related Pathways. Load more Abt-737 Interacts with ABT-737. ABT-737 is a small molecule BH3 mimetic inhibitor of the anti-apoptotic members of the BCL-2 family,  ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition  2 Apr 2016 ABT-737 is a BH3 mimetic that binds to and inhibits BCL-2, BCL-xL and BCL-w with high affinity but has a lower binding to MCL1 [23].

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